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Cowpox

Cowpox is a viral infection that is mainly found in Europe, particularly in the UK. Cowpox is found in wild rodents, most commonly in bank voles, wood mice, and field voles. Transmission from these animals to humans is rare. When a human does contract cowpox, symptoms are similar to what a person might experience after getting the smallpox vaccine, including a rash that develops where the skin touched the infected ulcer.

 

What Is Cowpox?

Cowpox is an infection caused by a virus. Cowpox is mainly found in Europe, particularly in the UK.
 

Cause of Cowpox

Cowpox is caused by the cowpox virus. The cowpox virus is within the family Poxviridae and the genus Orthopoxvirus. Other orthopoxviruses that cause infections in humans include:
 
Cowpox virus was used to make the first successful smallpox vaccine (today, the vaccinia virus is used).
 

Transmitting Cowpox

Cowpox most commonly is spread through direct contact with an infected ulcer on a cow's teat. It can also be transmitted through direct contact with an infected cat.
 
Cowpox is found in wild rodents, most commonly in bank voles, wood mice, and field voles, although transmission from these animals to humans is rare. There has been one proven case of rodent-to-human transmission. Other animals that can transmit cowpox include animals in zoos and circuses.
 
Person-to-person transmission has not been reported.
 

Cowpox Incubation Period

When a person becomes infected with the virus that causes cowpox, the virus begins to multiply within the body. After 9 to 10 days, cowpox symptoms can begin. This period between the transmission of cowpox and the start of cowpox symptoms is called the "cowpox incubation period."
 

Symptoms of Cowpox

Cowpox symptoms are similar to the symptoms one might experience after getting the smallpox vaccine.
 
The most common symptom of cowpox is a rash that develops where the skin touched the infected ulcer. This rash looks like one or more blisters, which then fill with pus, then form an ulcer, and eventually scab over with a thick black crust. Eventually, the rash will heal and scars will form. The rash does not spread.
 
Other symptoms of cowpox can include:
 
  • Swelling of lymph nodes
  • Red streaks from infected area to the armpit
  • Throbbing pain along the affected area
  • Fever
  • Chills
  • Loss of appetite
  • Muscle aches
  • Headache.
     

Diagnosing Cowpox

In order to make a diagnosis of cowpox, the doctor will ask a number of questions about:
 
  • Current symptoms
  • History of medical conditions
  • Family history of medical conditions or illnesses
  • Recent exposure to animals
  • Current medications.
     
The doctor will also perform a physical exam to look for signs and symptoms of cowpox. This will include a skin exam to look for the cowpox rash.
 
Before a diagnosis of cowpox is made, the doctor will consider other illnesses that can share common signs and symptoms with cowpox, including:
 

Treatment Options for Cowpox

There are currently no proven treatments that can kill the cowpox virus. Therefore, treatments for cowpox focus on providing relief of cowpox symptoms as the body fights the cowpox virus. This is called supportive care.
 
Supportive care as treatment for cowpox can include:
 
  • Medications to control fever or pain
  • Antibiotics and wound care to prevent secondary infections caused by bacteria.
     

Prognosis for Cowpox

In people with normal immune systems, cowpox improves within several weeks. Scars will remain, but there are no other long-term effects of cowpox.
 
In immunocompromised adults and children (especially those with atopic dermatitis), an infection with the cowpox virus may lead to an extensive rash over most parts of the body. In extreme cases, it can also cause death.
 
Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD