Rilonacept (Arcalyst®) is a medication used to treat a rare group of symptoms that cause inflammation in the body. Specifically, the drug is used to treat familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS), both of which belong to a group of hereditary autoinflammatory conditions called cryopyrin-associated periodic syndromes (CAPS). This prescription drug is an interleukin-1 beta (IL-1β) blocker. But how does rilonacept work?
Rilonacept works by blocking the actions of interleukin-1 beta (IL-1β), a certain protein of the immune system that causes inflammation in the body. People with CAPS have increased levels of IL-1β, which leads to inflammation in the body. By blocking the action of IL-1β, rilonacept reduces inflammation and symptoms associated with CAPS.
(For more information on this medication and its mechanism of action, click Rilonacept. This article provides a complete overview of the drug, including information on its uses, general precautions, and potential side effects.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Food and Drug Administration Web site. Vaccines, Blood and Biologics, Resources for Healthcare Providers. Available at: http://www.fda.gov/BiologicsBloodVaccines/ResourcesforYou/HealthcareProviders/default.htm. Accessed September 30, 2011.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click