Diseases Home > Side Effects of Tdap

Although most people respond well to Tdap, side effects are possible. In clinical studies, the most common problems that were reported with this vaccine included headache, fatigue, and injection site swelling, pain, or redness. While side effects of the vaccine are often mild, you should seek medical attention immediately if you experience a high fever, severe arm swelling, or any behavior changes.

An Introduction to Tdap Side Effects

As with all vaccines, side effects are possible with Tdap (Adacel®, Boostrix®). However, not everyone who receives the vaccine will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Tdap. Your healthcare provider can discuss a more complete list of Tdap side effects with you.)

Side Effects With Tdap to Report

There are a number of possible Tdap side effects that you should report to your healthcare provider. These include, but are not limited to:
  • Severe shoulder and/or upper arm pain (which may be a sign of a problem known as brachial neuritis)
  • Severe arm swelling
  • Weakness, tingling, or paralysis (which may be signs of Guillain-Barré syndrome)
  • A high fever
  • Any behavior changes
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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