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Tdap is a "booster" vaccine used for preventing pertussis (whooping cough), diphtheria, and tetanus in both adolescents and adults. It is given as a single, one-time injection into the upper arm. Although most people respond well to it, potential side effects include fever, headaches, and injection site swelling. After receiving the vaccine, all future boosters should be given as the Td (tetanus and diphtheria) vaccine.