Important Safety Concerns With Rilonacept

Specific Rilonacept Precautions and Warnings

Some warnings and precautions to be aware of prior to using this medication include the following:
 
  • Rilonacept may interfere with your body's ability to fight infections, which means you could develop potentially serious infections during treatment. If you have had tuberculosis in the past, your tuberculosis infection may come back. Contact your healthcare provider immediately if you get an infection or signs of an infection, such as:
 
 
  • It is unknown whether rilonacept treatment increases the risk for developing cancer. However, medications that suppress the immune system, such as rilonacept, have been associated with an increased cancer risk.
 
  • It is not uncommon for people who use this medicine to develop a skin reaction at the site of injection. In most cases, reactions are mild in nature and last one to two days. Talk to your healthcare provider if you experience a persistent or severe skin reaction. Reactions reported in clinical trials included the following:
 
    • Redness
    • Discomfort and pain
    • Swelling and inflammation
    • Itching
    • A mass or lumps
    • Bruising
    • Hives
    • Blisters
    • Warmth
    • Bleeding.
 
  • Although rare, some people may develop an allergic reaction to rilonacept. Seek immediate medical attention if you have signs of an allergic reaction, such as:
 
    • Skin rash
    • Hives
    • Swelling of the face or throat
    • Difficulty breathing or swallowing.
 
  • Vaccines may be less effective during rilonacept treatment. Also, you could become infected with the bacteria or viruses used to make the "live" vaccines (see Drug Interactions With Rilonacept). For this reason, it is generally recommended that people starting rilonacept receive all recommended vaccinations before beginning treatment. Your healthcare provider can tell you if you need any vaccinations.
 
  • You may develop high cholesterol (blood lipids) while using this medication. Your healthcare provider will monitor your lipid levels throughout treatment. If your levels increase too much, you may need to take cholesterol medications.
 
 
  • Rilonacept is a pregnancy Category C medication, which means it may not be safe for use during pregnancy (see Arcalyst and Pregnancy).
 
  • It is unknown if this medicine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Arcalyst and Breastfeeding).
 
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Rilonacept Drug Information

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