Methotrexate and Azathioprine as Sarcoidosis Medications

This medicine is taken once a week by mouth or injection, and usually takes up to six months to relieve symptoms.
This medicine may cause side effects, especially if you take high doses. These include:
  • Nausea.
  • Mouth sores.
  • A decrease in infection-fighting white blood cells. You then have a greater chance of getting an infection. If you take this medicine, you should have regular blood tests to check the levels of your white blood cells.
  • An allergic reaction in your lungs that goes away when you stop taking the medicine. This is extremely rare.
  • Liver damage. This is the most serious side effect. If you take methotrexate, you should be followed regularly by your physician.
If you are pregnant, you should not take this medicine.
Taking folic acid can help reduce your chances of having side effects from methotrexate.
Azathioprine (Imuran)
This medicine may work in about half of the people who have sarcoidosis. It is usually taken for at least six months. Side effects include:
  • Nausea
  • Reduced white blood cell levels, which can increase your chances of getting an infection.
This medicine has caused cancer in some people, especially when they have taken it at high doses.
If you are pregnant, you should not take this medicine.

Sarcoidosis Disease

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