Scleroderma is characterized by skin that progressively becomes hard and thickened. The condition occurs when immune cells activate, producing scar tissue in the skin, internal organs, and small blood vessels. Symptoms of the condition can also include Raynaud's phenomenon, joint stiffness in the hands, and skin ulcers on the fingers. For some people, scleroderma (particularly the localized forms) is fairly mild and resolves with time. However, others find that living with scleroderma has a significant effect on their quality of life.