Drug Interactions With Tdap

Certain medications and other vaccines may cause Tdap drug interactions. Some of these products include immunosuppressant medicines, tetanus immune globulin, and various other vaccines. These interactions may reduce the effectiveness of the vaccination, so it is best to avoid taking immunosuppressants or getting other vaccines if you are receiving Tdap.

An Overview of Drug Interactions With Tdap

Tdap (Adacel®, Boostrix®) can potentially interact with a few medications or other vaccines. Some of these medicines or vaccines that may lead to Tdap drug interactions include:
  • Immunosuppressant medications, including (but not limited to):


    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Cortisone
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Triamcinolone (Kenalog®



  • Other vaccines
  • Tetanus immune globulin.
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