Safety Concerns With the Oral Typhoid Vaccine

Live Typhoid Vaccine (Oral) Schedule
For this typhoid vaccine, four doses are given two days apart for each dose. The last dose should be given at least one week before travel to allow the vaccine time to work. A booster dose is needed every five years for people who remain at risk.
This typhoid vaccine should not be given to children younger than 6 years of age.

Who Should Not Get the Vaccine?

The following groups of people should not get the typhoid vaccine:
  • Anyone who has had a severe reaction to a previous dose of typhoid vaccine should not get another dose.
  • Anyone whose immune system is weakened should not get the oral typhoid vaccine. They should get the inactivated typhoid vaccine instead. These people include anyone who:
o Has HIV/AIDS or another disease that affects the immune system
o Is being treated with drugs that affect the immune system, such as steroids, for two weeks or longer
o Has any kind of cancer
o Is taking cancer treatment with x-rays or drugs.
The oral typhoid vaccine should not be given within 24 hours of certain antibiotics.

Possible Risks of Typhoid Fever Vaccine

Getting typhoid fever is much riskier than getting the typhoid vaccine. However, just like with any medicine, there are potential risks associated with the typhoid vaccine. Most of the problems that can occur are minor, meaning that they go away without treatment or are very easily treated by a healthcare provider. The risk of the typhoid vaccine causing serious harm, or even death, however, is extremely small.

What Is Typhoid?

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